No 2 days are the same. Factors like meals and shifts in daily routines may necessitate a complement to baseline therapy that can help improve symptom control when needed2,4
Why do your patients need an on-demand therapy?
Why do your patients need an on-demand therapy?
Slowed or delayed oral medication onset of action, which could be due to14:
GI dysfunction
High-protein meals
Morning OFF episodes
Patients report symptoms return unexpectedly14,15:
Tremor
Decreased dexterity
Stiffness/
freezing
Slowness
Balance problems
Weakness
On-demand treatment can be considered along with other symptom return management strategies
The shifting Parkinson’s disease treatment paradigm2
Adapted (changed colors and animated) from Isaacson SH, et al. Clin Park Relat Disord. 2022;7:100161; permission licensed under Creative Commons License Version 4.
Onset of OFF episodes
Adjust oral CD/LD
Addition of ON-extenders
Later addition of on-demand
OFF-episode therapy
Earlier addition of on-demand OFF-episode therapy
Adapted (changed colors and animated) from Isaacson SH, et al. Clin Park Relat Disord. 2022;7:100161; permission licensed under Creative Commons License Version 4.
Dr Falconer Video Series:
When Should Physicians Consider On‑Demand Therapies?
Dr Falconer is a board-certified neurologist and a trained movement specialist who works in the advanced care of patients with Parkinson's disease.
